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Washington University
School of Medicine
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Reliability and Validity of DSM and ICD
Substance Use Disorders
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Project Title |
Reliability and
Validity of DSM and ICD Substance Use Disorders |
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Funding Source |
NIH, NIDA |
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Project Dates |
1988 - 2001 |
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Project Number |
DA05585 |
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Team |
Principal Investigators-
Linda B. Cottler, Ph.D.
Co-Investigator-
Wilson Compton, M.D.
Edward Spitznagel, Ph.D.
Arbi Ben Abdallah, Ph.D. (ABD)
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Abstract
Begun in 1988, this reliability and validity
study (the "RV" study) has achieved a high level of productivity. Of note
is the heterogeneous study sample. In addition, funds from this grant have
allowed the investigators to continue development of a widely-used
non-clinician administered diagnostic instrument. The RV study is one of
only several grants funded by NIDA which have focused on the nosology of
substance use disorders. Although numerous findings and accomplishments
have been attributable to the RV study, unresolved issues concerning the
diagnosis of addiction and impairment remain. The investigators propose to
continue reliability studies with new respondent cohorts and to continue
validation studies through longitudinal evaluation of subjects previously
interviewed. Specifically, they propose: 1: To study the lingering issues
related to the classification of substance use disorders, highlighted by
the DSM-IV Substance Use Disorders Workgroup by interviewing new cohorts
of users of less-investigated substances, by continuing to analyze
previously collected data, and by following up previously interviewed
subjects to determine course, outcome and impairment to understand if: 1)
one set of criteria is appropriate for all substances and populations; b)
tolerance and physical withdrawal symptoms should be required for
dependence. Should the two withdrawal criteria (withdrawal symptoms and
withdrawal relief) be combined? C) social consequences and occupational
impairment should be excluded from the dependence concept; d) caffeine
dependence can be reliably and validly assessed; e) attention should be
given to abuse to make it more distinct and less a "residual" category; f)
dependence and abuse are best represented by a two factor concept of if
one factor underlies both. Are these factors different for each substance
and for different populations? G) the threshold number of criteria chosen
for abuse and dependence predicts course and outcome; h) compared to
DSM-III, III-R and ICD-10, the DSM-IV rates of abuse and dependence for
all substances differ cross-sectionally and longitudinally; i) the DSM-IV
clustering criterion is reliable and valid. 2) To continue the development
of a diagnostic instrument which assesses level of addiction, as well as
severity and remission, taking advantage of state of the art techniques
aimed at improving recall; 3) To continue methodological work on the
acceptability, feasibility, coverage and one-week test-retest reliability
of multiple dependence concepts focusing on prescribed, as well as
non-prescribed drugs of abuse, and adding drug using populations not
included in the original and first continuation of the RV study, such as
adolescents, chronic pain patients, and sedative-hypnotic abusers.
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Projects
National Monitoring of Adolescent Prescription Stimulants Study (N-MAPSS)
Prescription Drug Misuse,
Abuse and Dependence
Club Drug Use, Abuse, and Dependence
International Supplement
STD Supplement
Women
Teaching Women - (WTW)
Improving Treatment Services for Substance Abusers with Comorbid Depression
(SAD)
Sister
to Sister - (STS)
Nosology
Over-the-Counter Syringe Purchase in Four Communities
Analyses to Improve Reduction in Crack Use
Each
One Teach One - (EOTO)
Substance Abuse and Risk for AIDS - (SARA)
St.
Louis' Effort to Reduce the Spread of AIDS and IVDUs - (ERSA)
Community Based HIV Prevention Among Females at Risk in Bangalore INDIA
Deconstructing HIV Interventions Among Female Offenders
Enrolling and Retaining Female Offenders in HIV Trials
Collaborative MDMA and Other Club Drugs Study
Evaluating the Social Structure of a Local Heroin Market (NIDA-funded)
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Epidemiology and Prevention Research Group 
